Free BookHypoxia and Cancer Biological Implications and Therapeutic Opportunities (Cancer Drug Discovery and Development)

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Book Details :
Published on: 2013-11-09
Released on: 2013-11-09
Original language:

​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry. Trastuzumab Emtansine for HER2-Positive Advanced Breast ... Original Article. Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer. Sunil Verma M.D. David Miles M.D. Luca Gianni M.D. Ian E. Krop M.D. Ph.D ... DNA-Repair Defects and Olaparib in Metastatic Prostate ... Original Article. DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. Joaquin Mateo M.D. Suzanne Carreira Ph.D. Shahneen Sandhu M.D. Susana Miranda ... Hallmarks of Cancer: The Next Generation The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing ... Stephen W. Fesik - Vanderbilt-Ingram Cancer Center Profile of Stephen W. Fesik Vanderbilt-Ingram Cancer Center ... Stephen W. Fesik Ph.D. Co-Leader Signal Transduction and Chemical Biology Research Program Orrin H ... Targeting metastasis : Nature Reviews Cancer : Nature Research Targeting metastasis. Patricia S. Steeg 1 Journal name: Nature Reviews Cancer Volume: 16 Pages: 201218 Year published: (2016) DOI: doi:10.1038/nrc.2016.25 Funded Grants - Cancer Prevention Research Institute of Texas Funded Grants. Texas leads the nation in its commitment to the war on cancer. CPRIT has funded 1114 awards for cancer research product development and prevention ... The biology and function of fibroblasts in cancer : Nature ... The biology and function of fibroblasts in cancer. Raghu Kalluri 1 Journal name: Nature Reviews Cancer Volume: 16 Pages: 582598 Year published: (2016) MELATONIN: Uses Side Effects Interactions and Warnings ... Find patient medical information for MELATONIN on WebMD including its uses effectiveness side effects and safety interactions user ratings and products that have it. A comprehensive overview of exosomes as drug delivery ... a Laboratory for Cancer Biology Biomedicine Group Department of Health Science and Technology Aalborg University Fredrik Bajers Vej 3B 9220 Aalborg Denmark Downloads - Drug Discovery Today Open for collaboration an academic platform for drug discovery and development at SciLifeLab. SciLifeLab DDD is the national powerhouse for academic drug discovery in ...
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